CSL Research Acceleration Initiative 2023
CSL is a leading global biotech company that develops and delivers innovative biotherapies to help people living with life-threatening medical conditions live full lives.
CSL’s Research Acceleration Initiative aims to fast-track discovery of innovative biotherapies through partnerships between CSL and global research organizations. These partnerships provide funding and access to industry experts for scientists working on novel biotherapeutic strategies in CSL’s therapeutic areas.
Successful applicants will receive up to $400k over 2 years. Researchers who wish to apply are required to submit a non-confidential, 300 word online abstract by Feb. 23, 2023.
Interested researchers are invited to join an online information session to learn more. Webinar will be held on February 6, 2023, 4pmET/ 3pm CT/ 2pm MT/ 1pm PT.
For webinar links and online application instructions please contact Mitchell Fullerton ([email protected]).
The 2023 Research Acceleration Initiative will focus on research proposals that align with a CSL Therapeutic Area and are amenable to or include a Modality as illustrated below.
IMMUNOLOGY
Autoimmune diseases (AID)
Novel targets or biologic therapies for the treatment of AIDs including primary Sjögren’ssyndrome, systemic sclerosis, inflammatory idiopathic myopathies (including dermatomyositis) and autoimmune skin blistering diseases. We are seeking:
•Novel immunomodulatory strategies targeting cytokines, chemokines, modulatory proteins and TNF-family members
•Novel targets or biologic therapies involved in B cell depletion or B cell regulation
•Novel targets or biologic therapies involved in T cell regulation, T cell tolerance and T regulatory cell modulation
Alternatives to plasma-derived intravenous immunoglobulin (IVIG)
Synthetic or recombinant solutions to IVIG that are independent of plasma
HEMATOLOGY
Hemorrhagic stroke
•Novel biologic targets or therapies for the treatment of subarachnoid hemorrhage and intracerebral hemorrhage
•Biomarker or omics approaches for patient stratification and drug discovery
Acute ischemic stroke
•Novel biologic targets or therapies for the treatment of acute ischemic stroke, in particular anti-(thrombo-) inflammatory approaches as an adjunct to endovascular thrombectomy and pharmacological thrombolysis (tPA)
•Biomarker or omics approaches for patient stratification and drug discovery
Acute thrombosis (venous and arterial thrombosis)
Novel biologic therapies for targeted fibrinolysis / thrombolysis with increased safety and / or efficacy vs. standard of care in acute thrombotic conditions, in particular acuteischemic stroke and pulmonary embolism
RESPIRATORY
Idiopathic pulmonary fibrosis (IPF)and progressive pulmonary fibrosis (PPF)
•Novel biologic therapies or targets to treat IPF and PPF
•Omics approaches for patient stratification and drug discovery
Community acquired pneumonia (CAP)-associated complications
•Novel biologic therapies or targets to treat CAP-associated complications including acute respiratory distress syndrome (ARDS), sepsis, and acute kidney injury (AKI)
•Omics approaches for patient stratification and drug discovery
CARDIOVASCULAR AND METABOLIC
Myocarditis
Novel targets or biologic therapies for myocarditis
Dilated cardiomyopathy
Novel targets or biologic therapies for inflammatory dilated cardiomyopathy
Rare lipid disorders
Novel targets or biologic therapies (including gene therapies) for rare lipid disorders e.g.homozygous familial hypercholesterolemia
Severe forms of atherosclerosis
Novel targets or biologic therapies for severe atherosclerosis
TRANSPLANT
Chronic lung allograft dysfunction (CLAD)
•Novel biologic therapies or targets to prevent or treat CLAD, including approaches to establish tolerance / novel immunomodulation strategies
•Novel biomarkers for CLAD
Hematopoietic stem cell transplant (HSCT)
•Novel biologic therapies for the treatment and prevention of acute and chronic GvHD, including approaches to establish tolerance / novel immunomodulation strategies
•Novel biologic therapies that improve efficacy / safety of HSCT
Cardiovascular allograft vasculopathy (CAV)
•Novel biologic therapies for the treatment of CAV
•Animal models of CAV
GENE THERAPY
•In vivo kill switch or suicide switch
•Modulation of transgene expression in vivo
•Novel methods to select gene modified hematopoietic stem cells
•Novel gene therapies or gene therapy targets aligned with CSL’s Therapeutic Areas
•Non-viral in vivodelivery of ribonucleoproteins
VACCINES
mRNA and lipid nanoparticle platform
Innovative research addressing improved delivery, formulation, stabilization (5°C / room temperature), shelf-life extension and manufacturing technologies
Influenza virus antigen purity and yield enhancement
Innovative research with potential to impact yield and purity of influenza virus HA antigen produced in MDCK cell culture
Proven adjuvant technology