Columbia University

Technology Ventures

Academic Request for Proposals for Respiratory & Neonatology Therapeutic Targets

April 05, 2019

Chiesi is seeking research proposals for Respiratory and Neonatology therapeutic targets from academic medical centers, universities, and research institutions in North America and Europe.

We look forward to hearing from researchers and physician-scientists who are keen to collaborate with a global pharma company with a strong track record of translational R&D in respiratory and neonatology care.
Our objective is to award funds to validate early-stage projects with clear therapeutic potential. Successful applicants will be funded through sponsored research, with up to $280K (for North America) or €250K (for Europe) available per project for a minimum of one year and a maximum of two years’ duration. This should enable researchers to generate relevant preclinical data or demonstrate preclinical proof of concept, and help bring novel technologies to a mature enough state where they might be brought into the Chiesi pipeline and ultimately benefit patients.

What We Are Looking For
We are seeking therapeutic research projects in respiratory diseases and neonatology care with the following attributes:

•  Pre-clinical validation of potential therapeutic targets
•  Solid link between target and the etiopathogenesis and/or progression of a disease
•  Strong potential for clinical impact
•  Innovative experimental models developed to support the research
•  Small molecule and biologics as novel therapeutic agents will be considered, with
          •  Potential for intellectual property protection or strategy already developed
          •  Repurposing of known drugs for novel targets or new clinical indications

Therapeutic Areas of Interest for 2019
•  Respiratory: COPD; Severe Asthma; Interstitial Lung Diseases; Chronic Cough; Cystic Fibrosis; Non-CF Bronchiectasis; Pulmonary Arterial Hypertension; Acute Respiratory Distress Syndrome.
•  Neonatology: Bronchopulmonary Dysplasia; Neonatal Encephalopathy; Retinopathy of Prematurity; Neonatal Abstinence Syndrome.

Proposal Submission Process
The first step in the process is submission of a Pre-Proposal which should contain a brief, non-confidential 2-3 page overview of the target, mechanism (including evidence for link to disease), and the proposed therapeutic opportunity. A more detailed Full Proposal will be solicited by invitation only.

More Information
All investigators whose work meets these requirements are encouraged to apply.
Please download the Pre-Proposal template for opportunities in Respiratory here or Neonatology here and submit completed applications by April 5, 2019. 

For enquiries please contact: and CC

For submissions please send pre proposals to to be uploaded through the INPART CHIESI portal.


Key Dates
February 15, 2019 – Chiesi Academic RFP open
April 5, 2019 – Pre-Proposal submission deadline
June 21, 2019 – Full Proposal submission deadline* (Full Proposal solicitations by invitation only)
September 2019 – Awardees will be notified. Chiesi will work with the investigator’s institution to enter into a Sponsored Research Agreement (SRA). The research project may begin once the SRA is complete.
*Investigators will be given at least one month to prepare for Full Proposal submission.

Eligibility Criteria
To be eligible for funding, the applicant must be a research scientist or physician-scientist at an accredited university, academic medical center or research institution, located in North America or Europe (including Israel).

Application Process
The first step in the process is submission of a Pre-Proposal (deadline April 5, 2019). This must include only non-confidential information. If you are unsure, please consult with your Technology Transfer Office (TTO) or Office of Technology Development (OTD), or equivalent institutional representative prior to submission of the Pre-Proposal.  Following a favorable review of the Pre-Proposal, investigators will be invited to submit a more comprehensive Full Proposal (deadline June 21, 2019). Awardees will then be chosen from a shortlist of promising Full Proposals and will be notified in September 2019.

Pre-Proposal Submission Instructions
Please download the Pre-Proposal template for opportunities in Respiratory here or Neonatology here and submit completed applications by April 5, 2019. Please follow the submission instructions to be found in the template. The Pre-Proposal templates are hosted and managed by IN-PART.

Selection Criteria
Proposals will be reviewed by the respective Respiratory and Neonatology Scientific Review Committees, members of which are selected from Chiesi R&D. The research projects will be judged on several criteria, including: 
• Demonstration of Pre-clinical validation of the therapeutic target;
• Evidence of a solid link between the target and the etiopathogenesis and/or progression of a disease;
• Potential for intellectual property protection;
• Strength of prospective clinical impact.

Additional Information
For selected shortlisted Full Proposal submissions, Chiesi will communicate with the appropriate office at the investigator’s institution (Office of Technology Development, TTO, Office of Sponsored Programs, or equivalent) to discuss terms of the Sponsored Research Agreement (SRA) and work on the agreement.
Awardees will be notified in September 2019 and enter into an SRA with Chiesi. 
An SRA is a contract between the investigator’s institution and the sponsor (here Chiesi) for the purposes of funding and conducting research at the institution. The SRA will include the scope of the work to be performed by the investigator, the project budget, and will provide Chiesi with an option to intellectual property (IP) that may generated during the awardee’s research project.