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David Liu, Sam Sternberg unveil new way to insert big genes in human cells

Scientists led by Dr. Samuel Sternberg at Columbia University have improved upon a natural system called CRISPR-associated transposase, or CAST. It combines elements of the fabled gene editor with enzymes known as transposases that move so-called ‘jumping genes’ in and out of the genome.

Sidereal Therapeutics, a startup spun out of Dr. Jonathan Barasch's lab, won a $250K XSeed Award. Sidereal is developing first-in-class therapeutics for acute kidney injury and iron-mediated disorders. 

Scientists led by Dr. Samuel Sternberg at Columbia University have improved upon a natural system called CRISPR-associated transposase, or CAST. It combines elements of the fabled gene editor with enzymes known as transposases that move so-called ‘jumping genes’ in and out of the genome.

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